Pub. Date : 2020 Jan
PMID : 31628204
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | During tobacco and e-cigarette use, nicotine is mainly metabolized in the human liver by CYP2A6. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studies sought to validate a novel CYP2A6 inhibitor, (5-(4-ethylpyridin-3-yl)thiophen-2-yl)methanamine (DLCI-1), for its effects on intravenous nicotine self-administration. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 4 | Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studies sought to validate a novel CYP2A6 inhibitor, (5-(4-ethylpyridin-3-yl)thiophen-2-yl)methanamine (DLCI-1), for its effects on intravenous nicotine self-administration. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |