Title : Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression.

Pub. Date : 2019

PMID : 31613929






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression. Celecoxib AKT serine/threonine kinase 1 Homo sapiens
2 Phosphorylation of protein kinase B (Akt) and mammalian target of rapamycin (mTOR), as well as expression of COX-2 were significantly downregulated in cells treated with the combination of celecoxib and radiation compared with the radiation only group. Celecoxib AKT serine/threonine kinase 1 Homo sapiens
3 The result indicated that celecoxib exhibits radiosensitizing effects through COX-2 and Akt/mTOR-dependent mechanisms. Celecoxib AKT serine/threonine kinase 1 Homo sapiens