Title : The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase.

Pub. Date : 2019 Oct 29

PMID : 31611371






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase. Uracil apolipoprotein B mRNA editing enzyme catalytic subunit 3B Homo sapiens
2 A3B expression in UNG-null cells causes a buildup of genomic uracil, and the ensuing lethality requires processing of uracil lesions (likely U/G mispairs) by MSH2 and MLH1 (likely noncanonical MMR). Uracil apolipoprotein B mRNA editing enzyme catalytic subunit 3B Homo sapiens