Title : NO /RUNX3/kynurenine metabolic signaling enhances disease aggressiveness in pancreatic cancer.

Pub. Date : 2020 Jun 1

PMID : 31609478






1 Functional Relationships(s)
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1 Gene expression analysis in PDAC tumors (n = 63) showed a positive correlation between the expression of NOS2 and the tryptophan/kynurenine pathway genes, including indoleamine-2,3-dioxygenase 1 (IDO1) and several aryl hydrocarbon receptor (AHR)-target genes including NFE2L2 (NRF2), SERPINB2, IL1b, IL6 and IL8, which are implicated in pancreatic cancer. Kynurenine interleukin 1 beta Homo sapiens