Title : Spironolactone suppresses aldosterone-induced Kv1.5 expression by attenuating mineralocorticoid receptor-Nox1/2/4-mediated ROS generation in neonatal rat atrial myocytes.

Pub. Date : 2019 Dec 3

PMID : 31606204






1 Functional Relationships(s)
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1 The Aldo-induced upregulation of Kv1.5 was also reversed by the Src protein tyrosine kinase family inhibitor PP2, the Nox2 inhibitor gp91ds-tat and the Nox1/Nox4 inhibitor GKT137831 but not by the Rac GTPase inhibitor NSC23766. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus