Title : Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells.

Pub. Date : 2019 Nov 15

PMID : 31604821






1 Functional Relationships(s)
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1 In both tumor and healthy cells, V-ATPase inhibition induced a distinct metabolic regulatory cascade downstream of AMPK, affecting ATP and NADPH levels, glucose uptake, and reactive oxygen species (ROS) production. Adenosine Triphosphate 2,4-dienoyl-CoA reductase 1 Homo sapiens