Title : The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis.

Pub. Date : 2019 Oct 7

PMID : 31591388






1 Functional Relationships(s)
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1 Conversely, ectopic expression of mutant IDH1 or treatment of cells with cell-permeable D-2-HG promotes the accumulation of lipid reactive oxygen species (ROS) and subsequently ferroptosis. Oxygen isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens