Pub. Date : 2020 Feb
PMID : 31586149
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutant IDH produces R-2-hydroxyglutarate (R-2HG), which induces histone- and DNA-hypermethylation through the inhibition of epigenetic regulators, thus linking metabolism to tumorigenesis. | alpha-hydroxyglutarate | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Treatment of IDH1mut primary AML cells reduced 2-hydroxyglutarate levels (2HG) and induced myeloid differentiation in vitro. | alpha-hydroxyglutarate | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |