Pub. Date : 2019 Nov 20
PMID : 31585211
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inverse agonists of the 5-HT2A receptor reduce nicotine withdrawal signs in rats. | Nicotine | 5-hydroxytryptamine receptor 2A | Rattus norvegicus |
| 2 | Previous work has shown that chronic nicotine administration causes adaptive changes in 5-HT2A receptor expression. | Nicotine | 5-hydroxytryptamine receptor 2A | Rattus norvegicus |
| 3 | Based on this relationship, it was hypothesized that inactivating 5-HT2A receptors with the inverse agonists pimavanserin and volinanserin (MDL100907), would reduce the symptoms of nicotine withdrawal syndrome. | Nicotine | 5-hydroxytryptamine receptor 2A | Rattus norvegicus |
| 4 | The results suggest that the 5-HT2A receptor contributes to mediating nicotine withdrawal syndrome, and thus represents a potential target for interventions to aid smoking cessation. | Nicotine | 5-hydroxytryptamine receptor 2A | Rattus norvegicus |