Title : Intrathecal injection of dexmedetomidine ameliorates chronic neuropathic pain via the modulation of MPK3/ERK1/2 in a mouse model of chronic neuropathic pain.

Pub. Date : 2019 Dec

PMID : 31584354






3 Functional Relationships(s)
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Protein Name
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1 DEX markedly elevated the MKP3 expression and modestly reduced the MKP1 expression, with insignificant difference in the latter. Dexmedetomidine dual specificity phosphatase 6 Mus musculus
2 Furthermore, DEX significantly downregulated the phosphorylation of extracellular-signal-regulated kinase (ERK) 1/2, down-stream effector of MKP3 in CCI mice, whereas the downregulation was reversed by BCI. Dexmedetomidine dual specificity phosphatase 6 Mus musculus
3 Conclusion: We confirmed that DEX exerts the analgesic effect on chronic neuropathic pain via the regulation of MKP3/ERK1/2 signaling pathway, which may contribute to clarification of the molecular mechanism and novel therapy for chronic neuropathic pain. Dexmedetomidine dual specificity phosphatase 6 Mus musculus