Pub. Date : 2019 Oct 1
PMID : 31581548
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | This study showed that (i) the splice mutation in TP53 was present as an early driver mutation at diagnosis; (ii) the mutational profile was shared in pre- and post-NACT tumor samples; (iii) the complete expansion of a single dominant mutant clone through loss of heterozygosity (LOH) had occurred, suggesting a possible mechanism of platinum-resistance in HGSOC under the pressure of NACT. | Platinum | tumor protein p53 | Homo sapiens |