Title : Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation.

Pub. Date : 2019 Sep 30

PMID : 31570705






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The effect of dichloroacetate (DCA), a general pyruvate dehydrogenase kinase (PDK) inhibitor, on in vivo energy expenditure in ApoE-/- mice fed a western diet (WD) has not yet been investigated. Dichloroacetic Acid apolipoprotein E Mus musculus
2 WD-fed ApoE-/- mice developed atherosclerotic plaques and hyperlipidemia along with obesity, which were significantly ameliorated by DCA administration. Dichloroacetic Acid apolipoprotein E Mus musculus