Pub. Date : 2019 Dec
PMID : 31568920
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of p21 expression for anti-apoptotic activity of DDX3 against sanguinarine-induced cell death on intrinsic pathway. | sanguinarine | DEAD-box helicase 3 X-linked | Homo sapiens |
| 2 | PURPOSE: In this study, we aimed to study the bio-function of DDX3 anti-apoptotic activity in the intrinsic pathway using HeLa cells treated with sanguinarine. | sanguinarine | DEAD-box helicase 3 X-linked | Homo sapiens |
| 3 | DDX3 upregulated anti-apoptotic gene expression (Bcl-xL, cyclin D1, cyclin E, and cyclin B1) and downregulated pro-apoptotic gene expression (caspase-3, Bax) after sanguinarine treatment. | sanguinarine | DEAD-box helicase 3 X-linked | Homo sapiens |
| 4 | Overexpression and knockdown of DDX3 under sanguinarine-treated conditions showed that DDX3 inhibited p21 expression in sanguinarine-treated HeLa cells. | sanguinarine | DEAD-box helicase 3 X-linked | Homo sapiens |
| 5 | Overexpression and knockdown of DDX3 under sanguinarine-treated conditions showed that DDX3 inhibited p21 expression in sanguinarine-treated HeLa cells. | sanguinarine | DEAD-box helicase 3 X-linked | Homo sapiens |
| 6 | Overexpression and knockdown of DDX3 under sanguinarine-treated conditions showed that DDX3 inhibited p21 expression in sanguinarine-treated HeLa cells. | sanguinarine | DEAD-box helicase 3 X-linked | Homo sapiens |
| 7 | Overexpression and knockdown of DDX3 under sanguinarine-treated conditions showed that DDX3 inhibited p21 expression in sanguinarine-treated HeLa cells. | sanguinarine | DEAD-box helicase 3 X-linked | Homo sapiens |
| 8 | CONCLUSION: Taken together, the results suggest that the S90E residue is important for the regulation of p21 expression responsible for the anti-apoptotic activity of DDX3 in HeLa cells treated with sanguinarine. | sanguinarine | DEAD-box helicase 3 X-linked | Homo sapiens |
| 9 | A model of the antiapoptotic function of DDX3 on sanguinarine-treated HeLa cells was proposed to understand the molecular mechanism of the intrinsic apoptosis inhibition in cervical cancer cells. | sanguinarine | DEAD-box helicase 3 X-linked | Homo sapiens |