Title : Famotidine has a neuroprotective effect on MK-801 induced toxicity via the Akt/GSK-3β/β-catenin signaling pathway in the SH-SY5Y cell line.

Pub. Date : 2019 Dec 1

PMID : 31563592






3 Functional Relationships(s)
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1 Famotidine has a neuroprotective effect on MK-801 induced toxicity via the Akt/GSK-3beta/beta-catenin signaling pathway in the SH-SY5Y cell line. Famotidine AKT serine/threonine kinase 1 Homo sapiens
2 In this study, we aimed to investigate the effects of famotidine on the Akt/GSK-3beta/beta-catenin signaling pathway on SH-SY5Y neuroblastoma cells in the presence of MK-801. Famotidine AKT serine/threonine kinase 1 Homo sapiens
3 Overall, the present results suggest that famotidine has a neuroprotective effect against MK-801 via modulation of the Akt/GSK-3beta/beta-catenin signaling pathway, an important mechanism in schizophrenia neurobiology. Famotidine AKT serine/threonine kinase 1 Homo sapiens