Pub. Date : 2020
PMID : 31559898
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BMSC-derived leptin and IGFBP2 promote erlotinib resistance in lung adenocarcinoma cells through IGF-1R activation in hypoxic environment. | erlotinib | insulin like growth factor binding protein 2 | Homo sapiens |
| 2 | IGFBP2 counteracted the activation role of IGF-1 and induced erlotinib resistance by activating IGF-1R signaling in an IGF-1 independent manner. | erlotinib | insulin like growth factor binding protein 2 | Homo sapiens |
| 3 | IGFBP2 had synergistic effect with leptin to induce erlotinib resistance. | erlotinib | insulin like growth factor binding protein 2 | Homo sapiens |