Pub. Date : 2020 Feb
PMID : 31554962
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IkappaB/NF-kappaB/BACE1 signaling pathway. | baohuoside I | beta-secretase 1 | Rattus norvegicus |
| 2 | Moreover, ICS II not only exerted the inhibitory effect on LPS-induced IkappaB-alpha degradation and NF-kappaB activation, but also decreased the levels of Abeta1-40, Abeta1-42, amyloid precursor protein (APP) and beta secretase 1 (BACE1) in the astrocytes. | baohuoside I | beta-secretase 1 | Rattus norvegicus |
| 3 | Moreover, ICS II not only exerted the inhibitory effect on LPS-induced IkappaB-alpha degradation and NF-kappaB activation, but also decreased the levels of Abeta1-40, Abeta1-42, amyloid precursor protein (APP) and beta secretase 1 (BACE1) in the astrocytes. | baohuoside I | beta-secretase 1 | Rattus norvegicus |
| 4 | Interestingly, molecular docking revealed that ICS II might directly bind to BACE1. | baohuoside I | beta-secretase 1 | Rattus norvegicus |