Title : Plasmin effect on platelet glycoprotein Ib-von Willebrand factor interactions.

Pub. Date : 1985 Jan

PMID : 3155489






2 Functional Relationships(s)
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1 Plasmin, 0.05 to 1.0 CU/mL, reduced ristocetin-mediated agglutination of washed platelets in the presence of von Willebrand factor (vWF) from 66% of control to 2% of control, following a one-hour incubation. Ristocetin plasminogen Homo sapiens
2 By use of an enzyme-linked immunosorbent assay (ELISA) based immunoinhibition assay for glycocalicin, we were able to demonstrate that plasmin treatment of washed platelets released a glycocalicin-related antigen into the surrounding medium and that appearance of this material corresponding to loss of vWF-dependent, ristocetin-induced agglutination. Ristocetin plasminogen Homo sapiens