Title : Dipyridamole Enhances the Cytotoxicities of Trametinib against Colon Cancer Cells through Combined Targeting of HMGCS1 and MEK Pathway.

Pub. Date : 2020 Jan

PMID : 31554653






2 Functional Relationships(s)
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1 Here, we identified that HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1), the rate-limiting enzyme of the MVA pathway, is overexpressed in colon cancer tissues and positively regulates the cell proliferation, migration and invasion of colon cancer cells. Mevalonic Acid 3-hydroxy-3-methylglutaryl-CoA synthase 1 Homo sapiens
2 Here, we identified that HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1), the rate-limiting enzyme of the MVA pathway, is overexpressed in colon cancer tissues and positively regulates the cell proliferation, migration and invasion of colon cancer cells. Mevalonic Acid 3-hydroxy-3-methylglutaryl-CoA synthase 1 Homo sapiens