Title : Structural, Thermodynamic, and Kinetic Traits of Antiestrogen-Compounds Selectively Targeting the Y537S Mutant Estrogen Receptor α Transcriptional Activity in Breast Cancer Cell Lines.

Pub. Date : 2019

PMID : 31552220






1 Functional Relationships(s)
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1 Here, we identified five molecules active on recurrent Y537S ERalpha polymorphism by employing in silico virtual screening on commercial databases of molecules, complemented by ER-transactivation and MTT assays in MCF7 and MDA-MB-231 breast cancer cells expressing wild type or mutated ERalpha. thiazolyl blue estrogen receptor 1 Homo sapiens