Pub. Date : 2020
PMID : 31550726
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVES: We assessed whether treatment with an orally available inhibitor of autotaxin (ATXi), the main LPA-producing enzyme, could slow the progression of chronic allograft injury in a fully major histocompatibility complex-mismatched rat kidney transplant model and compared its effects with those of the angiotensin-converting enzyme inhibitor lisinopril. | lysophosphatidic acid | ectonucleotide pyrophosphatase/phosphodiesterase 2 | Rattus norvegicus |
| 2 | OBJECTIVES: We assessed whether treatment with an orally available inhibitor of autotaxin (ATXi), the main LPA-producing enzyme, could slow the progression of chronic allograft injury in a fully major histocompatibility complex-mismatched rat kidney transplant model and compared its effects with those of the angiotensin-converting enzyme inhibitor lisinopril. | lysophosphatidic acid | ectonucleotide pyrophosphatase/phosphodiesterase 2 | Rattus norvegicus |
| 3 | RESULTS: Renal LPA levels were increased in allograft rats, providing the rationale for using ATXi in this model. | lysophosphatidic acid | ectonucleotide pyrophosphatase/phosphodiesterase 2 | Rattus norvegicus |