Title : ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.

Pub. Date : 2019 Oct

PMID : 31548609






4 Functional Relationships(s)
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Protein Name
Organism
1 By contrast, OSBP-mediated cholesterol trafficking drives constitutive mTORC1 activation in a disease model caused by the loss of the lysosomal cholesterol transporter, Niemann-Pick C1 (NPC1). Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens
2 By contrast, OSBP-mediated cholesterol trafficking drives constitutive mTORC1 activation in a disease model caused by the loss of the lysosomal cholesterol transporter, Niemann-Pick C1 (NPC1). Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens
3 By contrast, OSBP-mediated cholesterol trafficking drives constitutive mTORC1 activation in a disease model caused by the loss of the lysosomal cholesterol transporter, Niemann-Pick C1 (NPC1). Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens
4 By contrast, OSBP-mediated cholesterol trafficking drives constitutive mTORC1 activation in a disease model caused by the loss of the lysosomal cholesterol transporter, Niemann-Pick C1 (NPC1). Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens