Title : Investigation of Phospholipase Cγ1 Interaction with SLP76 Using Molecular Modeling Methods for Identifying Novel Inhibitors.

Pub. Date : 2019 Sep 23

PMID : 31548507






1 Functional Relationships(s)
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1 Indeed, molecular modeling of PLCgamma1 with SLP76 peptide and with previously reported inhibitors (ritonavir, anethole, daunorubicin, diflunisal, and rosiglitazone) facilitated the identification of the common critical residues (Gln805, Arg806, Asp808, Glu809, Asp825, Gly827, and Trp828) as well as the quantification of their interaction through binding energies calculations. Diflunisal lymphocyte cytosolic protein 2 Homo sapiens