Title : Genome profiling revealed the activation of IL2RG/JAK3/STAT5 in peripheral T‑cell lymphoma expressing the ITK‑SYK fusion gene.

Pub. Date : 2019 Nov

PMID : 31545408






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 JAK3-selective inhibitor tofacitinib abrogated the phosphorylation of downstream signalling molecule STAT5, supressed cell growth, induced cell apoptosis and arrested the cell cycle at the G1/S phase in ITK-SYK+ Jurkat cells. tofacitinib Janus kinase 3 Homo sapiens