Pub. Date : 2020 Jan
PMID : 31531888
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b. | Docetaxel | NADH:ubiquinone oxidoreductase subunit A13 | Homo sapiens |
| 2 | This study aims to clarify the potential role and molecular mechanisms of GRIM-19 on the response of PC cells to chemical drug docetaxel. | Docetaxel | NADH:ubiquinone oxidoreductase subunit A13 | Homo sapiens |
| 3 | Knockdown of GRIM-19 increased the resistance of PC cells to docetaxel, and overexpression of GRIM-19 promoted docetaxel-induced apoptotic death in PC cells. | Docetaxel | NADH:ubiquinone oxidoreductase subunit A13 | Homo sapiens |
| 4 | Knockdown of GRIM-19 increased the resistance of PC cells to docetaxel, and overexpression of GRIM-19 promoted docetaxel-induced apoptotic death in PC cells. | Docetaxel | NADH:ubiquinone oxidoreductase subunit A13 | Homo sapiens |
| 5 | overexpression of Rad23b reversed GRIM-19-mediated response to docetaxel in PC cells. | Docetaxel | NADH:ubiquinone oxidoreductase subunit A13 | Homo sapiens |
| 6 | GRIM-19 promoted the sensitivity of PC cells to docetaxel by downregulating Rad23b, which may serve as a promising target to develop a better strategy of chemotherapy for PC. | Docetaxel | NADH:ubiquinone oxidoreductase subunit A13 | Homo sapiens |