Title : [Cancer cell-specific functional relation between Na+,K+-ATPase and volume-regulated anion channel].

Pub. Date : 2019

PMID : 31527358






1 Functional Relationships(s)
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1 Recently, we found that the receptor-type Na+,K+-ATPase, which has no pumping activity, is associated with leucine-rich repeat-containing 8 family, member A(LRRC8A), one of the components of volume-regulated anion channel (VRAC), in the membrane microdomains of plasma membrane of cancer cells, and that this crosstalk contributes to the inhibition of the cancer cell growth by sub-muM cardiac glycosides. Glycosides leucine rich repeat containing 8 VRAC subunit A Homo sapiens