Pub. Date : 2020 Jan
PMID : 31526948
19 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin stabilizes p53 by interaction with NAD(P)H:quinone oxidoreductase 1 in tumor-derived cell lines. | Curcumin | tumor protein p53 | Homo sapiens |
| 2 | Curcumin is a natural phytochemical with potent anti-neoplastic properties including modulation of p53. | Curcumin | tumor protein p53 | Homo sapiens |
| 3 | The purpose of this study was to describe a mechanism by which curcumin restores p53 levels in human cancer cell lines. | Curcumin | tumor protein p53 | Homo sapiens |
| 4 | Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. | Curcumin | tumor protein p53 | Homo sapiens |
| 5 | Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. | Curcumin | tumor protein p53 | Homo sapiens |
| 6 | Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. | Curcumin | tumor protein p53 | Homo sapiens |
| 7 | Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. | Curcumin | tumor protein p53 | Homo sapiens |
| 8 | Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. | Curcumin | tumor protein p53 | Homo sapiens |
| 9 | Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. | Curcumin | tumor protein p53 | Homo sapiens |
| 10 | Interestingly, the cell viability assay after treatment with curcumin showed that the cytotoxic activity was selectively higher in cervical cancer cells contained wild type p53 but not in breast cancer cells contained mutated p53. | Curcumin | tumor protein p53 | Homo sapiens |
| 11 | Interestingly, the cell viability assay after treatment with curcumin showed that the cytotoxic activity was selectively higher in cervical cancer cells contained wild type p53 but not in breast cancer cells contained mutated p53. | Curcumin | tumor protein p53 | Homo sapiens |
| 12 | The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP). | Curcumin | tumor protein p53 | Homo sapiens |
| 13 | The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP). | Curcumin | tumor protein p53 | Homo sapiens |
| 14 | Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53. | Curcumin | tumor protein p53 | Homo sapiens |
| 15 | Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53. | Curcumin | tumor protein p53 | Homo sapiens |
| 16 | Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53. | Curcumin | tumor protein p53 | Homo sapiens |
| 17 | Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53. | Curcumin | tumor protein p53 | Homo sapiens |
| 18 | Our findings suggest that the use of curcumin may reactivate the p53 pathway in cancer cells with p53 wild-type. | Curcumin | tumor protein p53 | Homo sapiens |
| 19 | Our findings suggest that the use of curcumin may reactivate the p53 pathway in cancer cells with p53 wild-type. | Curcumin | tumor protein p53 | Homo sapiens |