Title : Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial‑ mesenchymal transition via the AKT/GSK‑3β/Snail signaling pathway.

Pub. Date : 2019 Sep

PMID : 31524255






4 Functional Relationships(s)
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1 Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial- mesenchymal transition via the AKT/GSK-3beta/Snail signaling pathway. Resveratrol AKT serine/threonine kinase 1 Homo sapiens
2 The results revealed that resveratrol treatment and AKT1 knockdown significantly inhibited cell migration and invasion in colon cancer, and markedly increased E-cadherin expression and decreased that of N-cadherin, phospho (p)-AKT1, p-GSK-3beta, and Snail in colon cancer both in vitro and in vivo. Resveratrol AKT serine/threonine kinase 1 Homo sapiens
3 Furthermore, the effects of resveratrol were significantly weaker in the AKT1-knockdown cells. Resveratrol AKT serine/threonine kinase 1 Homo sapiens
4 In conclusion, resveratrol may suppress the invasion and metastasis of colon cancer through reversal of EMT via the AKT/GSK-3beta/Snail signaling pathway. Resveratrol AKT serine/threonine kinase 1 Homo sapiens