Title : Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesis.

Pub. Date : 2019 Dec

PMID : 31523901






3 Functional Relationships(s)
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1 Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesis. Nocodazole mitotic arrest deficient 2 like 1 Homo sapiens
2 In SiHa cells, knockdown of Mad2 and BubR1 increased cell growth, reinforced invasion capacity and migration potency, inhibited apoptosis and decreased G2-phase distribution after nocodazole treatment. Nocodazole mitotic arrest deficient 2 like 1 Homo sapiens
3 Downregulation of Mad2 and BubR1 increase the malignant behavior and nocodazole resistance of SiHa cells via causing spindle assembly checkpoint defect. Nocodazole mitotic arrest deficient 2 like 1 Homo sapiens