Title : Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.

Pub. Date : 2019 Nov 4

PMID : 31506280






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mechanistic studies revealed that CDK7 inhibition markedly reduces glutathione levels and increases reactive oxygen species due to reduced expression of NRF2 and glutathione biosynthesis genes. Oxygen cyclin-dependent kinase 7 Mus musculus