Title : NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.

Pub. Date : 2019 Nov 1

PMID : 31501246






2 Functional Relationships(s)
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1 NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90. Adenosine-5'-(N-ethylcarboxamide) heat shock protein 90 beta family member 1 Homo sapiens
2 We found that derivatives that lengthen the 5" moiety of NECA improve selectivity for Grp94 over Hsp90alpha. Adenosine-5'-(N-ethylcarboxamide) heat shock protein 90 beta family member 1 Homo sapiens