Pub. Date : 2019 Oct
PMID : 31499335
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, the mechanistic and clinical significance of the effect of PD-L1 on TCs versus ICs remains unclear. | 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide | CD274 molecule | Homo sapiens |
| 2 | METHODS: We evaluated PD-L1 expression on TCs and ICs using Ventana SP263 assay and the stromal M2 TAM distribution using CD163 staining in 160 consecutive patients with resected non-small cell lung cancer (NSCLC). | 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide | CD274 molecule | Homo sapiens |
| 3 | RESULTS: PD-L1 expression on TCs and ICs was significantly higher in stromal M2 TAM-high group than in stromal M2 TAM-low group (p < 0.001 and p < 0.001, respectively). | 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide | CD274 molecule | Homo sapiens |
| 4 | Regarding the clinical significance of PD-L1, PD-L1 expression on TCs was significantly associated with histology (p = 0.001), tumor differentiation (p < 0.001) and nodal status (p = 0.029). | 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide | CD274 molecule | Homo sapiens |
| 5 | Regarding the clinical significance of PD-L1, PD-L1 expression on TCs was significantly associated with histology (p = 0.001), tumor differentiation (p < 0.001) and nodal status (p = 0.029). | 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide | CD274 molecule | Homo sapiens |
| 6 | CONCLUSIONS: During tumor progression in NSCLC, the presence of M2 TAMs might affect PD-L1 expression both on TCs and ICs. | 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide | CD274 molecule | Homo sapiens |
| 7 | In patients with NSCLC, PD-L1 expression both on TCs and ICs was associated with malignant behaviors, which was more in case of ICs. | 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide | CD274 molecule | Homo sapiens |