Title : Synthesis of 2-Arylindoles by Rhodium-Catalyzed/Copper-Mediated Annulative Coupling of N-Aryl-2-aminopyridines and Propargyl Alcohols via Selective C-H/C-C Activation.

Pub. Date : 2019 Sep 20

PMID : 31496256






1 Functional Relationships(s)
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1 Highly selective C-C bond cleavage of gamma-substituted tert-propargyl alcohols occurred, together with pyridine-directed ortho C(sp2)-H bond activation, affording a series of 2-arylindoles with yields up to 90%. pyridine Sp2 transcription factor Homo sapiens