Title : Glycyrrhetinic acid pretreatment attenuates liver ischemia/reperfusion injury via inhibiting TLR4 signaling cascade in mice.

Pub. Date : 2019 Nov

PMID : 31493667






2 Functional Relationships(s)
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1 Besides, further analysis indicated that GA pretreatment reduced I/R-induced expression of extracellular HMGB1, inhibited activation of TLR4 and following phosphorylation of IRAK1, ERK, P38 and NF-kappaB, and attenuated TNF-alpha and IL-1beta production. Glycyrrhetinic Acid high mobility group box 1 Mus musculus
2 These data suggested that GA protected against liver I/R injury through a HMGB1-TLR4 signaling pathway and it might be a promising drug for future clinical use in liver transplantation. Glycyrrhetinic Acid high mobility group box 1 Mus musculus