Pub. Date : 2020 Jan
PMID : 31493242
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The cation-chloride cotransporters Na+-K+-2Cl--1 (NKCC1) and K+-2Cl--2 (KCC2) critically regulate neuronal responses to gamma-aminobutyric acid (GABA). | gamma-Aminobutyric Acid | solute carrier family 12, member 2 | Mus musculus |
| 2 | The cation-chloride cotransporters Na+-K+-2Cl--1 (NKCC1) and K+-2Cl--2 (KCC2) critically regulate neuronal responses to gamma-aminobutyric acid (GABA). | gamma-Aminobutyric Acid | solute carrier family 12, member 2 | Mus musculus |
| 3 | NKCC1 renders GABA excitatory in immature neurons while expression of KCC2 signals GABA maturation to its inhibitory role. | gamma-Aminobutyric Acid | solute carrier family 12, member 2 | Mus musculus |
| 4 | Imbalances in NKCC1/KCC2 alter GABA neurotransmission, which may contribute to hyperexcitability and blunted inhibition in neurocircuitry after neonatal exposure to anesthesia. | gamma-Aminobutyric Acid | solute carrier family 12, member 2 | Mus musculus |