Title : Genome-wide association studies of 74 plasma metabolites of German shepherd dogs reveal two metabolites associated with genes encoding their enzymes.

Pub. Date : 2019 Sep 6

PMID : 31493001






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Two associations were located around genes which encode for enzymes for the relevant metabolites: 4-hydroxyproline was significantly associated to D-amino acid oxidase (DAO), and threonine to L-threonine 3-dehydrogenase (LOC477365). Hydroxyproline D-amino acid oxidase Canis lupus familiaris
2 Two associations were located around genes which encode for enzymes for the relevant metabolites: 4-hydroxyproline was significantly associated to D-amino acid oxidase (DAO), and threonine to L-threonine 3-dehydrogenase (LOC477365). Hydroxyproline D-amino acid oxidase Canis lupus familiaris
3 Three of the top ten haplotypes associated to 4-hydroxyproline included at least one SNP on DAO. Hydroxyproline D-amino acid oxidase Canis lupus familiaris
4 CONCLUSION: DAO and LOC477365 were identified as candidate genes affecting the natural plasma concentration of 4-hydroxyproline and threonine, respectively. Hydroxyproline D-amino acid oxidase Canis lupus familiaris