Pub. Date : 2019 Nov 30
PMID : 31491605
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. | mono-(2-ethylhexyl)phthalate | signal transducer and activator of transcription 5A | Rattus norvegicus |
| 2 | Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. | mono-(2-ethylhexyl)phthalate | signal transducer and activator of transcription 5A | Rattus norvegicus |
| 3 | We aim to clarify the effects of JAK2/STAT5 pathway on lipid accumulation induced by MEHP and the role of oxidation stress in NAFLD. | mono-(2-ethylhexyl)phthalate | signal transducer and activator of transcription 5A | Rattus norvegicus |
| 4 | MEHP down-regulated the expression and inhibited the activation of JAK2/STAT5. | mono-(2-ethylhexyl)phthalate | signal transducer and activator of transcription 5A | Rattus norvegicus |
| 5 | Therefore, we concluded that MEHP led to lipid accumulation through inhibiting JAK2/STAT5 pathway, resulted in damaging liver parenchyma and NAFLD by aggravating oxidation stress. | mono-(2-ethylhexyl)phthalate | signal transducer and activator of transcription 5A | Rattus norvegicus |