Title : EP2 Receptor Blockade Attenuates COX-2 Upregulation During Intestinal Inflammation.

Pub. Date : 2020 Sep

PMID : 31490357






2 Functional Relationships(s)
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1 In this study, we evaluate the effect of blockade of the low affinity pro-inflammatory receptors EP1 and EP2 on expression of COX-2, the rate limiting enzyme in PGE2 biosynthesis, and on gut barrier permeability using cultured enterocytes and three different models of intestinal injury. Dinoprostone prostaglandin E receptor 2 Rattus norvegicus
2 PGE2 upregulated COX-2 in IEC-6 enterocytes, and this response was blocked by the EP2 antagonist PF-04418948, but not by the EP1 antagonist ONO-8711 or EP4 antagonist E7046. Dinoprostone prostaglandin E receptor 2 Rattus norvegicus