Title : Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.

Pub. Date : 2019 Dec

PMID : 31490091






1 Functional Relationships(s)
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1 Radiosensitization by IC87361 and olaparib was significantly enhanced under acute anoxia and chronic hypoxia.Conclusions: The DNA-PK inhibitors KU57788 and IC87361 are more effective radiosensitizers than the PARP-1 inhibitors olaparib and veliparib at non-cytotoxic concentrations in HNSCC cell cultures and their activity is enhanced by SLFN11 and hypoxia. 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one schlafen family member 11 Homo sapiens