Pub. Date : 2020 Feb
PMID : 31489998
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Guanylate-binding protein-2 inhibits colorectal cancer cell growth and increases the sensitivity to paclitaxel of paclitaxel-resistant colorectal cancer cells by interfering Wnt signaling. | Paclitaxel | guanylate binding protein 2 | Homo sapiens |
| 2 | Guanylate-binding protein-2 inhibits colorectal cancer cell growth and increases the sensitivity to paclitaxel of paclitaxel-resistant colorectal cancer cells by interfering Wnt signaling. | Paclitaxel | guanylate binding protein 2 | Homo sapiens |
| 3 | In this study, the authors are determined to dig into the role that GBP-2 plays in the sensitivity of CRC to PTX, therefore, possibly indicating a promising gene therapy target for CRC. | Paclitaxel | guanylate binding protein 2 | Homo sapiens |
| 4 | The level of GBP-2 mRNA and protein in PTX-resistant CRC cell lines was significantly lower than in nonresistant cell lines. | Paclitaxel | guanylate binding protein 2 | Homo sapiens |
| 5 | Forced exogenous expression of GBP-2 in PTX-resistant CRC cell lines resulted in more sensitivity to PTX because of the demonstration of less cell proliferation, invasion, and more apoptosis. | Paclitaxel | guanylate binding protein 2 | Homo sapiens |
| 6 | Forced exogenous expression of GBP-2 in PTX-resistant CRC cell lines resulted in more sensitivity to PTX because of the demonstration of less cell proliferation, invasion, and more apoptosis. | Paclitaxel | guanylate binding protein 2 | Homo sapiens |
| 7 | GBP-2 upregulation could enhance the killing effect of PTX in both PTX-sensitive CRC cells and PTX-resistant CRC cells by suppressing Wnt signaling. | Paclitaxel | guanylate binding protein 2 | Homo sapiens |
| 8 | GBP-2 upregulation could enhance the killing effect of PTX in both PTX-sensitive CRC cells and PTX-resistant CRC cells by suppressing Wnt signaling. | Paclitaxel | guanylate binding protein 2 | Homo sapiens |
| 9 | GBP-2 upregulation could enhance the killing effect of PTX in both PTX-sensitive CRC cells and PTX-resistant CRC cells by suppressing Wnt signaling. | Paclitaxel | guanylate binding protein 2 | Homo sapiens |