Title : Nir2 Is an Effector of VAPs Necessary for Efficient Hepatitis C Virus Replication and Phosphatidylinositol 4-Phosphate Enrichment at the Viral Replication Organelle.

Pub. Date : 2019 Nov 15

PMID : 31484747






7 Functional Relationships(s)
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Protein Name
Organism
1 VAPs are known to recruit lipid transfer proteins to the ER, including oxysterol binding protein (OSBP), which has been previously shown to be necessary for cholesterol delivery to the HCV replication organelle in exchange for phosphatidylinositol 4-phosphate [PI(4)P]. pi(4)p oxysterol binding protein Homo sapiens
2 VAPs are known to recruit lipid transfer proteins to the ER, including oxysterol binding protein (OSBP), which has been previously shown to be necessary for cholesterol delivery to the HCV replication organelle in exchange for phosphatidylinositol 4-phosphate [PI(4)P]. pi(4)p oxysterol binding protein Homo sapiens
3 We propose that Nir2 functions to replenish phosphoinositides at the HCV replication organelle to maintain elevated steady-state levels of PI(4)P, which is removed by OSBP. pi(4)p oxysterol binding protein Homo sapiens
4 Elevated levels of phosphatidylinositol 4-phosphate [PI(4)P] in HCV replication organelles (ROs) recruits lipid transfer proteins (LTPs), like oxysterol-binding protein (OSBP). pi(4)p oxysterol binding protein Homo sapiens
5 Elevated levels of phosphatidylinositol 4-phosphate [PI(4)P] in HCV replication organelles (ROs) recruits lipid transfer proteins (LTPs), like oxysterol-binding protein (OSBP). pi(4)p oxysterol binding protein Homo sapiens
6 OSBP exchanges PI(4)P with cholesterol, thus removing PI(4)P from the HCV RO. pi(4)p oxysterol binding protein Homo sapiens
7 OSBP exchanges PI(4)P with cholesterol, thus removing PI(4)P from the HCV RO. pi(4)p oxysterol binding protein Homo sapiens