Title : Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma.

Pub. Date : 2019 Nov 1

PMID : 31479685






1 Functional Relationships(s)
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1 Evaluations on multiple representative HCC subtypes (HepG2, Hep3B and HuH7) suggested that the disrupted pH homeostasis would amplify the lactate stress to initiate HCC apoptosis, while at the same time also suppressing their migration and invasion abilities. Lactic Acid MIR7-3 host gene Homo sapiens