Pub. Date : 2019 Nov
PMID : 31472452
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | UGT1A8 was inhibited by 97.6%, 94.8%, 86.3%, 83.4% and 77.1% by PFDA, PFTA, perfluorooctadecanoic acid (PFOcDA), PFDoA and PFOS, respectively. | perfluorodecanoic acid | UDP glucuronosyltransferase family 1 member A8 | Homo sapiens |
| 2 | PFDA and PFOS exhibited competitive inhibition towards UGT1A1, and PFDA and PFTA showed competitive inhibition towards UGT1A8. | perfluorodecanoic acid | UDP glucuronosyltransferase family 1 member A8 | Homo sapiens |
| 3 | The values were calculated to be 0.3 mumoL/L and 1.3 mumoL/L for the in vivo inhibition of PFDA towards UGT1A1-and UGT1A8-catalyzed metabolism of substances, and 0.2 mumoL/L and 2.0 mumoL/L for the inhibition of PFOS towards UGT1A1 and the inhibition of PFTA towards UGT1A8, respectively. | perfluorodecanoic acid | UDP glucuronosyltransferase family 1 member A8 | Homo sapiens |
| 4 | The values were calculated to be 0.3 mumoL/L and 1.3 mumoL/L for the in vivo inhibition of PFDA towards UGT1A1-and UGT1A8-catalyzed metabolism of substances, and 0.2 mumoL/L and 2.0 mumoL/L for the inhibition of PFOS towards UGT1A1 and the inhibition of PFTA towards UGT1A8, respectively. | perfluorodecanoic acid | UDP glucuronosyltransferase family 1 member A8 | Homo sapiens |