Title : Neuroinflammatory Reactions in the Brain of 1,2-DCE-Intoxicated Mice during Brain Edema.

Pub. Date : 2019 Aug 27

PMID : 31461951






3 Functional Relationships(s)
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1 Our results revealed that subacute poisoning by 1,2-DCE upregulates protein levels of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), interleukin-1beta (IL-1beta), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), inducible nitric oxide synthase (iNOS) and p-p65 in mouse brains. ethylene dichloride interleukin 1 beta Mus musculus
2 Our results revealed that subacute poisoning by 1,2-DCE upregulates protein levels of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), interleukin-1beta (IL-1beta), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), inducible nitric oxide synthase (iNOS) and p-p65 in mouse brains. ethylene dichloride interleukin 1 beta Mus musculus
3 Lastly, pretreatment with an antagonist against the IL-1beta receptor also attenuates changes in protein levels of p-p38 MAPK, p-p65, p-IkappaB, VCAM -1, ICAM-1, IL-1beta, and Iba-1 in the brain of 1,2-DCE-intoxicated-mice. ethylene dichloride interleukin 1 beta Mus musculus