Title : Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice.

Pub. Date : 2019 Sep 28

PMID : 31454532






1 Functional Relationships(s)
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1 As for macrophage M1/M2 polarization in liver, nano-celastrol reduced the expression of macrophage M1 biomarkers (e.g., IL-6, IL-1beta, TNF-alpha, iNOS) in a dose-dependent manner and marginally increased the expression of macrophage M2 biomarkers (e.g., Arg-1, IL-10). celastrol interleukin 1 beta Mus musculus