Title : Epigenetic reduction of miR-214-3p upregulates astrocytic colony-stimulating factor-1 and contributes to neuropathic pain induced by nerve injury.

Pub. Date : 2020 Jan

PMID : 31453981






1 Functional Relationships(s)
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1 Treatment with the DNMT inhibitor zebularine significantly reduced cytosine methylation in the miR-214-3p promoter; this reduced methylation consequently increased the expression of miR-214-3p and decreased the content of CSF1 in the ipsilateral dorsal horn, and further, attenuated IL-6 production and pain behavior in rats with SNL. pyrimidin-2-one beta-ribofuranoside colony stimulating factor 1 Rattus norvegicus