Title : Targeting PI3K/Akt/mTOR Pathway Identifies Differential Expression and Functional Role of IL8 in Liver Cancer Stem Cell Enrichment.

Pub. Date : 2019 Nov

PMID : 31439713






2 Functional Relationships(s)
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1 Following IL-8 inhibition with its receptor inhibitor Reparixin or siRNA knockdown, LCSC features of HCC cells were repressed and sensitivity of cells to Sorafenib increased significantly. Sorafenib C-X-C motif chemokine ligand 8 Homo sapiens
2 Furthermore, inflammatory cytokines (IL-8, IL-1beta and IL-11) were also up-regulated upon treatment with HCC approved kinase inhibitors Sorafenib and Regorafenib. Sorafenib C-X-C motif chemokine ligand 8 Homo sapiens