Title : 17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase.

Pub. Date : 2019 Oct 25

PMID : 31439665






1 Functional Relationships(s)
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1 Mechanistically, E2 enhanced the interaction of membrane ERalpha with the Galpha subunit Galphai-2/3, which then transactivated particulate guanylate cyclase-A (pGC-A) to produce cGMP, thereby activating protein kinase G type I (PKG-I). Cyclic GMP natriuretic peptide receptor 1 Homo sapiens