Pub. Date : 2019 Sep
PMID : 31429533
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin ameliorates cuprizone-induced reduction of hippocampal neurogenesis, brain-derived neurotrophic factor, and phosphorylation of cyclic AMP response element-binding protein in the mouse dentate gyrus. | Cuprizone | brain derived neurotrophic factor | Mus musculus |
| 2 | Moreover, cuprizone administration decreased glucose utilization (GLUT3-positive cells) and cell transcription (pCREB-positive cells and BDNF protein expression) in the dentate gyrus. | Cuprizone | brain derived neurotrophic factor | Mus musculus |
| 3 | CONCLUSION: The results of the study suggest that cuprizone treatment disrupts hippocampal neurogenesis in the dentate gyrus by reducing BDNF levels and decreasing the phosphorylation of CREB. | Cuprizone | brain derived neurotrophic factor | Mus musculus |