Pub. Date : 2020 Feb
PMID : 31417158
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | We have examined the influence of functionally distinct classes of AHR ligands on the levels of Niemann-Pick C1-like intracellular cholesterol transporter (NPC1L1) and enzymes involved in the cholesterol synthesis pathway. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | NPC1L1 is known to mediate the intestinal absorption of dietary cholesterol and is clinically targeted. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 4 | AHR ligands were capable of attenuating cholesterol uptake through repression of NPC1L1 expression. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 5 | Transcription of NPC1L1 and genes of the cholesterol synthesis pathway is predominantly regulated by SREBP-2, especially after treatment with a statin. | Cholesterol | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |