Title : FDA-approved drug screen identifies proteasome as a synthetic lethal target in MYC-driven neuroblastoma.

Pub. Date : 2019 Oct

PMID : 31406244






2 Functional Relationships(s)
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1 A combination screen reveals the proteasome inhibitor bortezomib (BTZ) and the histone deacetylase (HDAC) inhibitor vorinostat (SAHA) concertedly induce dramatic cell death in part through synergistic activation of BAX. Vorinostat BCL2 associated X, apoptosis regulator Homo sapiens
2 A combination screen reveals the proteasome inhibitor bortezomib (BTZ) and the histone deacetylase (HDAC) inhibitor vorinostat (SAHA) concertedly induce dramatic cell death in part through synergistic activation of BAX. Vorinostat BCL2 associated X, apoptosis regulator Homo sapiens